Content before wireframes.

Starting with the content helps focus the message you’re delivering to your users. When you build the design out from there, you can more easily determine where the appropriate places are for each type of communication. The site map and hierarchy are born out of the real content that will exist in the final product. You end up with a more cohesive and clear experience.

via Steph Hay – Content-first User Experience » UIE Brain Sparks.